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twiist by Sequel

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The twiist™ AID System is designed for individuals with type 1 diabetes ages 6 and older. It automates insulin delivery based on real-time continuous glucose monitoring (CGM) data, predicted glucose trends, and user-defined parameters. The system is intended to support flexible, personalized therapy with simplified settings designed to accommodate a range of individual lifestyles and multiple wear options for added discretion and comfort. The twiist AID System allows for full iPhone control and supports bolus delivery from Apple Watch.

At the core of the system is twiist Loop, an adaptive algorithm derived from the original open-source Loop platform created by and for people living with diabetes. twiist Loop adjusts basal insulin delivery in real time based on CGM data, predicted glucose values, and individualized targets. The algorithm offers a high degree of customization, including the ability to set a broad glucose correction range (87–180 mg/dL) and modify meal entries retroactively.

The system incorporates iiSure™ Technology, which directly measures the volume of each insulin micro-dose as it is delivered. This real-time verification enables earlier detection and alert of insulin delivery issues including occlusions.

For more information, visit twiist by Sequel

Activity Settings:
Yes, the Workout Preset allows user to temporarily adjust target prior to and/or during exercise
Automatic Correction Boluses:
No
Closed Loop Functionality:
Yes
Automatic Insulin Adjustments:
Yes
Calibration Not Required:
Yes
Compatible CGM:
FreeStyle Libre 3 Plus sensor available. Eversense 365 compatibility planned for future release. 
Waterproof:
No; IP24 indicating protection from splashing water.
Medicare Covered:
NA yet
Remote Software Update Capability:
Yes
Multiple Languages:
No
Bolus Management Smartphone:
Yes, iPhone and connected Apple Watch
Food Database:
No
Additional Features:
  • Carb absorption easily selected using food emojis that reflect food types and absorption times (fast, medium and slow carb effects)
  • 3-ways to bolus: On-pump, via smartphone or Apple Watch
  • Correction is delivered via automated basal adjustments over 30 minutes
  • Retroactive meal adjustments
  • Pre-meal and exercise presets
  • iiSure™ technology directly measures the volume of insulin delivered and includes 4 checkpoints along the way to help ensure accurate delivery
  • Glucose target range: 87 mg/dL - to 180mg/dL

Size Weight:
Dimensions: 5.9 cm x 5.5 cm x 1.7 cm Weight: < 2.0 oz
Approved For Ages:
6 years and up
Tubeless:
No
Battery:
Rechargeable lithium ion
Reservoir Capacity:
300 Units/3 mL
Infusion Set:
The primary infusion set for the twiist system is the Smiths Medical Cleo 90 Infusion Set. Please refer to the twiist user guide for a detailed list of compatible infusion sets.
Basal Range:
  • Basal rates can be entered with a minimum value of 0.00 units per hour and a maximum value of 30 units per hour and can be edited in increments of 0.05 units per hour. The minimum basal rate of delivery is 0.1 units per hour.
  • Basal rates may be set in 30 minute intervals throughout the day.
Bolus Range:
Programmable from 0.05 units in 0.01 unit increments; maximum is 25 units
Transmitter Range:
The maximum distance for communication between the iPhone and the twiist pump is 33 feet or 10 meters.

Details coming soon.

    Pharmacy availability

    The twiist Savings Program reduces out-of-pocket costs for the twiist AID System. 

    Contact Customer Care at 1-877-4twiist (894478) for more information.

    View the danatech Diabetes Technology Affordability Program Finder Tool for Affordability Program

    The twiist™ Automated Insulin Delivery (AID) System powered by Tidepool includes three components:
    • the twiist™ alternate controller enabled (ACE) insulin infusion pump;
    • the twiist™ Loop interoperable automated glycemic controller (iAGC) algorithm; and
    • a compatible integrated continuous glucose monitor (iCGM).
    Indications for Use
    • The twiist System is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription.
    • The twiist Loop algorithm is intended for use with compatible integrated continuous glucose monitors (iCGMs) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user's confirmation, control the delivery of correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of Type 1 diabetes mellitus in persons six years of age and greater. The twiist Loop is intended for single patient use and requires a prescription.
    • The twiist Automated Insulin Delivery System includes a simple bolus calculator available when Loop is off. It is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator entered blood glucose, insulin sensitivity, insulin to carbohydrate ratio, target glucose values, and current insulin on board.
    Contraindications
    The twiist automated insulin delivery system is not intended for anyone unable or unwilling to:
    • Test blood glucose (BG) levels as recommended by their healthcare provider.
    • Maintain sufficient diabetes selfcare skills.
    • See their healthcare provider regularly.
    • Demonstrate adequate carbohydrate-counting skills (preferred, not required).
    The user must not:
    • Have difficulty seeing.
    • Have difficulty hearing.
    • Have deficient cognitive capabilities.
    • Have physical impairments which would make operating the pump or iPhone difficult.

    Please visit twiist.com/safety for important safety information. Product not yet available outside of the U.S.


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    DISCLAIMERS: 

    This site and its services do not constitute the practice of medical advice, diagnosis or treatment. Always talk to your diabetes care and education specialist or health care provider for diagnosis and treatment, including your specific medical needs. If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately. To find a diabetes care and education specialist near you, visit the ADCES finder tool.

    ADCES and danatech curate product specifics and periodically review them for accuracy and relevance. As a result, the information may or may not be the most recent. We recommend visiting the manufacturer's website for the latest details if you have any questions.

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